Ammonium formate → N-(5-aminopyridin-2-yl)-2-phenylacetamide

HRID 1921822

Reaktionsgleichung

Reaktionsgleichung von HRID 1921822
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([NH:10][C:11](=[O:19])[CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[N:8][CH:9]=1)([O-])=O.C([O-])=O.[NH4+]>CCO.CCOC(C)=O.[Pd]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([NH:10][C:11](=[O:19])[CH2:12][C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=2)=[N:8][CH:9]=1

Komponenten

6

Edukt 2

HCID 2723923Ammonium formateHCID 4350143N-(5-nitropyridin-2-yl)-2-phenylacetamide

Produkt 1

HCID 43144587N-(5-aminopyridin-2-yl)-2-phenylacetamide

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

A solution of N-(5-nitropyridin-2-yl)-2-phenylacetamide (4.35 g, 16.9 mmol) in EtOH (75 mL) and EtOAc (75 mL) is stirred at rt and ammonium formate (4.27 g) and 10% Pd/C (500 mg) are added. The mixture is heated at reflux for 30 min, cooled, filtered through celite and evaporated to afford the title compound as an off-white solid which was used without further purification.

Aufarbeitung

  1. temperatureThe mixture is heated
  2. temperatureat reflux for 30 min
  3. temperaturecooled
  4. filtrationfiltered through celite
  5. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-9867299630f643cdaf4402d3a1d86ca3
Quelldatensatz
uspto-grants-2012_05
Patentnummer
US08173656B2

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