Ammonium formate → N-(5-aminopyridin-2-yl)-2-phenylacetamide

HRID 1924972

Reaktionsgleichung

Reaktionsgleichung von HRID 1924972
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([NH:10][C:11](=[O:19])[CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[N:8][CH:9]=1)([O-])=O.C([O-])=O.[NH4+]>CCO.CCOC(C)=O.[Pd]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([NH:10][C:11](=[O:19])[CH2:12][C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=2)=[N:8][CH:9]=1

Komponenten

6

Edukt 2

HCID 2723923Ammonium formateHCID 4350143N-(5-nitropyridin-2-yl)-2-phenylacetamide

Produkt 1

HCID 43144587N-(5-aminopyridin-2-yl)-2-phenylacetamide

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

A solution of N-(5-nitropyridin-2-yl)-2-phenylacetamide (4.35 g, 16.9 mmol) in EtOH (75 mL) and EtOAc (75 mL) is stirred at rt and ammonium formate (4.27 g) and 10% Pd/C (500 mg) are added. The mixture is heated at reflux for 30 min, cooled, filtered through celite and evaporated to afford the title compound as an off-white solid which was used without further purification.

Aufarbeitung

  1. temperatureThe mixture is heated
  2. temperatureat reflux for 30 min
  3. temperaturecooled
  4. filtrationfiltered through celite
  5. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-68ab21eba2024c3e896a6a776b240239
Quelldatensatz
uspto-grants-2012_05
Patentnummer
US08178530B2

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