1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → (4-Benzyloxy-phenyl)-acetic acid hydrazide

HRID 1927249Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1927249
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][C:16]([OH:18])=O)=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O.NN.CCN=C=NCCCN(C)C.C1C=CC2N(O)[N:40]=[N:39]C=2C=1>O.C(N(CC)CC)C.C1COCC1>[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][C:16]([NH:39][NH2:40])=[O:18])=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

8

Edukt 4

HCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 24654Hydrazine hydrate (1:1)HCID 757711-HydroxybenzotriazoleHCID 810334-Benzyloxyphenylacetic acid

Produkt 1

HCID 59287387(4-Benzyloxy-phenyl)-acetic acid hydrazideAusbeute 16,2 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 962WaterLösungsmittelHCID 8028TetrahydrofuranLösungsmittelHCID 8471TriethylamineLösungsmittel

Versuchsvorschrift

To a solution of THF (50 mL) of 4-benzyloxy-phenylacetic acid (7.0 g) were added hydrazine monohydrate (4.3 g), WSC (6.7 g), HOBt (4.7 g), and triethylamine (3.5 g), which was stirred for 15 hours at room temperature. Water was added to the reaction mixture, and the precipitated solids were filtered off to obtain the titled compound (1.2 g).

Aufarbeitung

  1. filtrationthe precipitated solids were filtered off

Quellen und Nachweise

ORD-Eintrag
ord-24b96b4c1d894617bd44b1326dfa6a2e
Quelldatensatz
uspto-grants-2012_05
Patentnummer
US08183264B2

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