Lactide → Lactide-caprolactone coploymer

HRID 1929267

Reaktionsgleichung

Reaktionsgleichung von HRID 1929267
[CH3:1][CH:2]1[O:9][C:7](=[O:8])[CH:6]([CH3:10])[O:5][C:3]1=[O:4].[C:11]1(=[O:18])[O:17][CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1>[Sn].C(O)CCCCCCCCCCC>[CH3:1][CH:2]1[O:9][C:7](=[O:8])[CH:6]([CH3:10])[O:5][C:3]1=[O:4].[C:11]1(=[O:18])[O:17][CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1

Komponenten

5

Edukt 2

HCID 7272LactideHCID 10401epsilon-CAPROLACTONE

Produkt 1

HCID 123633Lactide-caprolactone coploymerAusbeute 74,9 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 81931-DodecanolKatalysatorHCID 5352426Tin atomKatalysator

Reaktionsbedingungen

Temperatur
160 °C

Versuchsvorschrift

Next, 72.3 grams (0.50 moles) of DL-lactide (Purac) was weighed and placed into the round-bottom flask. Then 57.1 grams (0.50 moles) of ε-caprolactone (Fluka) was weighed and placed in the flask. To this mixture was added 5.6 mL (0.025 moles) of dodecanol and 0.1 mL of the Tin catalyst. The round-bottom flask was placed in an oil bath and heated at 160° C. for 18 hours with stirring by a magnetic stirring bar. The flask was cooled to 110° C. and a vacuum was pulled for 12 hours to remove any residual monomer. The flask was then cooled to room temperature, the vacuum released, and the thick viscous liquid polymer transferred to a sealed glass container. A total of 96.7 grams of the viscous liquid polymer was obtained. The molecular weight (MW) of the copolymer as determined by gel permeation chromatography with a multi-angle light-scattering detector (GPC-MALS) was 8250 daltons with a polydispersity (MW/MN) of 1.13.

Aufarbeitung

  1. customThe round-bottom flask was placed in an oil bath
  2. temperatureThe flask was cooled to 110° C.
  3. customto remove any residual monomer
  4. temperatureThe flask was then cooled to room temperature

Quellen und Nachweise

ORD-Eintrag
ord-31758408cbc548d1a2c95bca4ba40e26
Quelldatensatz
uspto-grants-2012_05
Patentnummer
US08187640B2

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