Acetic Acid → HCID 58376142, Verbindung
Reaktionsgleichung
[CH2:1]([N:8]([CH2:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)[CH2:9][CH2:10][N:11]1[C:16]2[CH:17]=C(C#N)[C:19]([F:21])=[CH:20][C:15]=2[O:14][C:13]([CH3:25])([CH3:24])[C:12]1=[O:26])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.O.[C:36]([OH:39])(=[O:38])[CH3:37]>>[CH2:1]([N:8]([CH2:27][C:28]1[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=1)[CH2:9][CH2:10][N:11]1[C:16]2[CH:17]=[C:37]([C:36]([OH:39])=[O:38])[C:19]([F:21])=[CH:20][C:15]=2[O:14][C:13]([CH3:25])([CH3:24])[C:12]1=[O:26])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1Komponenten
5
Versuchsvorschrift
4-[2-(Dibenzylamino)ethyl]-7-fluoro-2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-6-carbonitrile (588 mg) was dissolved in acetic acid (5 ml), and thereto was added conc. hydrochloric acid (5 ml), and the mixture was refluxed for 75 hours. The reaction solution was cooled, and thereto was added water, and filtered. The solid collected by filtration was washed with water and dried at 70° C. for 18 hours to give the title compound (406 mg).