Isobutylamine → N-(2-methylpropyl)cyclopentanamine

Temperatur

70 °C

A mixture of cyclopentanone (10 g, 0.12 mol) and isobutyl amine (29.5 ml, 0.297 mol) was heated at 70° C. for 3 h under nitrogen. After cooling to 0° C., absolute ethanol (50 ml) was added to the reaction mixture, followed by sodium borohydride (6.59 g, 0.178 mol) in portions. The reaction mixture stirred at RT for 12 h, the solvent was removed under vacuum. The residue was taken up in MTBE and washed with water and brine. The organic layer was dried over Na2SO4, evaporated to dryness and the crude was purified by chromatography using silica gel (60-120 mesh), dichloromethane\methanol as eluent to afford of the titled compound as a yellow liquid.

1. temperatureAfter cooling to 0° C.
2. customthe solvent was removed under vacuum
3. washwashed with water and brine
4. dry with materialThe organic layer was dried over Na2SO4
5. customevaporated to dryness
6. customthe crude was purified by chromatography

ORD-Eintrag

ord-0e81c911447b48efbf21dfe4b58644d4

Quelldatensatz

uspto-grants-2013_03

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08399448B2