Water → 1-ethyl-2-(4-methylphenyl)-5-nitro-1H-pyrrolo[2,3-b]pyridine

To a suspension of potassium ter-butoxide (0.41 g, 3.7 mmol) in anhydrous DMF (5 ml) a solution of 5-nitro-3-(phenylethynyl)pyridin-2-amine (0.70 g, 2.8 mmol), in DMF (25 ml) was added dropwise while stirring at room temperature. After 1.5 days, iodoethane (0.38 ml, 4.7 mmol) was added and the whole stirred for additional 1.5 days. To the reaction H2O (50 ml) and EtOAc (100 ml) were then added. The mixture was poured into a separatory funnel, the organic layer separated, the aqueous one thoroughly extracted with EtOAc (50 ml) and combined organic layers washed with brine (2×100 ml). The organic solvent was removed by evaporation under reduced pressure and the residue was purified by column chromatography on silica gel (Et2O/n-hexane, Et2O 10%→20%) to give 1-ethyl-2-(4-methylphenyl)-5-nitro-1H-pyrrolo[2,3-b]pyridine:

1. stirringthe whole stirred for additional 1.5 days
2. additionwere then added
3. additionThe mixture was poured into a separatory funnel
4. customthe organic layer separated
5. extractionthe aqueous one thoroughly extracted with EtOAc (50 ml)
6. washwashed with brine (2×100 ml)
7. customThe organic solvent was removed by evaporation under reduced pressure
8. customthe residue was purified by column chromatography on silica gel (Et2O/n-hexane, Et2O 10%→20%)

ORD-Eintrag

ord-6cdf0e183c69461bb77f94ad9a654af6

Quelldatensatz

uspto-grants-2013_03

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08399477B2