Oxalyl chloride → HCID 25255278, Verbindung
Reaktionsgleichung
C(Cl)(=O)C(Cl)=O.[CH3:7][C:8]1[CH:9]=[C:10]([CH:14]=[CH:15][C:16]=1[N:17]1[CH2:22][CH2:21][O:20][CH2:19][CH2:18]1)[C:11]([OH:13])=O.[F:23][C:24]1[CH:25]=[CH:26][C:27]([O:34][CH3:35])=[C:28]([C:30](=[N:32]O)[NH2:31])[CH:29]=1.CCN(C(C)C)C(C)C>>[F:23][C:24]1[CH:25]=[CH:26][C:27]([O:34][CH3:35])=[C:28]([C:30]2[N:31]=[C:11]([C:10]3[CH:14]=[CH:15][C:16]([N:17]4[CH2:22][CH2:21][O:20][CH2:19][CH2:18]4)=[C:8]([CH3:7])[CH:9]=3)[O:13][N:32]=2)[CH:29]=1Komponenten
5
Versuchsvorschrift
Oxalyl chloride (138 μL; 1.63 mmol; 3 eq.), Intermediate 35 (120 mg; 0.54 mmol; 1 eq.), Intermediate 23 (100 mg; 0.54 mmol, 1 eq.) and DIEA (280 μL; 1.63 mmol; 3 eq.) were reacted according to general procedure 2. Purification by precipitation from DCM/c-hexane afforded the title compound as a yellow solid.