Acetic Acid → HCID 10527264, Verbindung

HRID 1953666Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1953666
[CH3:1][N:2]1[C:6]2=[N:7][C:8]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)=[CH:9][CH:10]=[C:5]2[N:4]=[C:3]1[CH2:17][O:18][C:19]1[CH:51]=[CH:50][C:22]([CH2:23][CH:24]2[S:28][C:27](=[O:29])[N:26](C(C3C=CC=CC=3)(C3C=CC=CC=3)C3C=CC=CC=3)[C:25]2=[O:49])=[CH:21][CH:20]=1.C(O)(=O)C>O>[CH3:1][N:2]1[C:6]2=[N:7][C:8]([C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=3)=[CH:9][CH:10]=[C:5]2[N:4]=[C:3]1[CH2:17][O:18][C:19]1[CH:51]=[CH:50][C:22]([CH2:23][CH:24]2[S:28][C:27](=[O:29])[NH:26][C:25]2=[O:49])=[CH:21][CH:20]=1

Komponenten

4

Edukt 2

HCID 176Acetic AcidHCID 107947135-{4-(3-Methyl-5-phenylimidazo[5,4-b]pyridin-2-ylmethoxy)benzyl}-3-triphenylmethylthiazolidine-2,4-dione

Produkt 1

HCID 10527264HCID 10527264, VerbindungAusbeute 72,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A procedure similar to that described in Example 12 was repeated, except that 0.9 g of 5-{4-(3-methyl-5 -phenylimidazo[5,4-b]pyridin-2-ylmethoxy)benzyl}-3-triphenylmethylthiazolidine-2,4-dione (prepared as described in Preparation 111) was treated with 36 ml of a 3:1 by volume mixture of acetic acid and water. After working up the product as described in Example 12, the resulting crude product was crystallized by trituration with ethyl acetate, to give 420 mg of the title compound, melting at 211-213° C.

Aufarbeitung

  1. customthe resulting crude product was crystallized by trituration with ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-e61f64e5487943c9afc3e69df10c8f9f
Quelldatensatz
uspto-grants-2000_09
Patentnummer
US06117893

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