Iodoethane → dimethyl N-(7-nitro-2,3-dimethoxyquinoxalin-5-ylmethyl)-alpha-(ethylamino)ethylphosphonate

HRID 1953780Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1953780
[N+:1]([C:4]1[CH:13]=[C:12]2[C:7]([N:8]=[C:9]([O:16][CH3:17])[C:10]([O:14][CH3:15])=[N:11]2)=[C:6]([CH2:18][NH:19][CH:20]([P:22](=[O:27])([O:25][CH3:26])[O:23][CH3:24])[CH3:21])[CH:5]=1)([O-:3])=[O:2].[CH2:28](I)[CH3:29].C(N(C(C)C)CC)(C)C>C(#N)C>[N+:1]([C:4]1[CH:13]=[C:12]2[C:7]([N:8]=[C:9]([O:16][CH3:17])[C:10]([O:14][CH3:15])=[N:11]2)=[C:6]([CH2:18][N:19]([CH2:28][CH3:29])[CH:20]([P:22](=[O:27])([O:23][CH3:24])[O:25][CH3:26])[CH3:21])[CH:5]=1)([O-:3])=[O:2]

Komponenten

5

Edukt 3

HCID 6340IodoethaneHCID 81531DiisopropylethylamineHCID 23297975Dimethyl N-(7-Nitro-2,3-dimethoxyquinoxalin-5-ylmethyl)-alpha-aminoethylphosphonate

Produkt 1

HCID 23298022dimethyl N-(7-nitro-2,3-dimethoxyquinoxalin-5-ylmethyl)-alpha-(ethylamino)ethylphosphonate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

300 mg (0.75 mmol) of dimethyl N-(7-nitro-2,3-dimethoxyquinoxalin-5-ylmethyl)-α-aminoethylphosphonate, 0.482 ml (8 eq.) of ethyl iodide and 1.4 ml (11 eq.) of diisopropylethylamine are stirred at 700 for 24 hours in 10 ml of acetonitrile. The reaction mixture is evaporated and the residue is stirred in diethyl ether. The solid is filtered off, washed with diethyl ether and the filtrate is evaporated. The title compound is obtained as a brownish oil.

Aufarbeitung

  1. customThe reaction mixture is evaporated
  2. filtrationThe solid is filtered off
  3. washwashed with diethyl ether
  4. customthe filtrate is evaporated

Quellen und Nachweise

ORD-Eintrag
ord-a2966ee69d99414abdb20a20e52a4394
Quelldatensatz
uspto-grants-2000_09
Patentnummer
US06117873

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