Water → 2-(4-Methoxyphenyl)benzonitrile

HRID 1954483

Reaktionsgleichung

Reaktionsgleichung von HRID 1954483
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([Mg]Br)=[CH:5][CH:4]=1.Br[C:12]1[CH:19]=[CH:18][CH:17]=[CH:16][C:13]=1[C:14]#[N:15].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.O>O1CCCC1.[Pd](Cl)Cl>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:12]2[C:13]([C:14]#[N:15])=[CH:16][CH:17]=[CH:18][CH:19]=2)=[CH:5][CH:4]=1

Komponenten

7

Edukt 4

HCID 962WaterHCID 11776TriphenylphosphineHCID 162722-BromobenzonitrileHCID 178491912HCID 178491912, Verbindung

Produkt 1

HCID 13933732-(4-Methoxyphenyl)benzonitrileAusbeute 94 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 24290Palladium ChlorideKatalysatorHCID 8028TetrahydrofuranLösungsmittel2×

Versuchsvorschrift

4-methoxyphenylmagnesium bromide (280 g, 15% solution in tetrahydrofuran) is added dropwise over seven hours to a refluxing solution of 2-bromobenzonitrile (32 g), palladium (II) chloride (1.3 g) and triphenylphosphine (3.8 g) in tetrahydrofuran (210 ml). [HPLC: yield 94-95%]. After cooling to room temperature and the addition of water (50 ml), tetrahydrofuran is removed under vacuum. The residue is extracted with toluene (230 ml). Insoluble material is filtered off and the solvent distilled off. The crude product is recrystallised from ethanol to give 4'-methoxybiphenyl-2-carbonitrile as a solid, m.pt. 82-83° C. 1H NMR (CDCl3): 3.90(s,3H), 7.02(d,2H), 7.36-7.52(m,4H), 7.59-7.65(m,1H), 7.74(d,1H).

Aufarbeitung

  1. customis removed under vacuum
  2. extractionThe residue is extracted with toluene (230 ml)
  3. filtrationInsoluble material is filtered off
  4. distillationthe solvent distilled off
  5. customThe crude product is recrystallised from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-4748a8aea93e43cfbe529d93cc49aef3
Quelldatensatz
uspto-grants-2000_09
Patentnummer
US06121480

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