Lithium Hydroxide → HCID 59363504, Verbindung

HRID 1957929Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1957929
[CH3:1][N:2]1[CH:6]=[C:5]([NH:7][C:8]([NH:10][C:11]2[CH:16]=[CH:15][C:14]([O:17][C:18]([F:21])([F:20])[F:19])=[CH:13][CH:12]=2)=[O:9])[CH:4]=[C:3]1[C:22]([O:24]CC)=[O:23].[OH-].[Li+]>C1COCC1.O>[CH3:1][N:2]1[CH:6]=[C:5]([NH:7][C:8]([NH:10][C:11]2[CH:12]=[CH:13][C:14]([O:17][C:18]([F:20])([F:21])[F:19])=[CH:15][CH:16]=2)=[O:9])[CH:4]=[C:3]1[C:22]([OH:24])=[O:23]

Komponenten

5

Edukt 2

HCID 3939Lithium HydroxideHCID 59363501HCID 59363501, Verbindung

Produkt 1

HCID 59363504HCID 59363504, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

470 mg (1.27 mmol) of ethyl 1-methyl-4-[({[4-(trifluoromethoxy)phenyl]amino}carbonyl)amino]-1H-pyrrole-2-carboxylate are initially charged in 5 ml of THF, 152 mg (6.33 mmol) of lithium hydroxide in 1 ml of water are added and the mixture is stirred under reflux overnight. The reaction mixture is concentrated, the residue is acidified with 2M hydrochloric acid and the precipitate formed is filtered off with suction and dried under reduced pressure. This gives a solid.

Aufarbeitung

  1. temperatureunder reflux overnight
  2. concentrationThe reaction mixture is concentrated
  3. customthe precipitate formed
  4. filtrationis filtered off with suction
  5. customdried under reduced pressure
  6. customThis gives a solid

Quellen und Nachweise

ORD-Eintrag
ord-ca89fc13e2a14b1f8278ccb967f19dcb
Quelldatensatz
uspto-grants-2013_04
Patentnummer
US08410090B2

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