Pyridine → HCID 58446806, Verbindung

HRID 1958343Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1958343
Br.[NH2:2][C:3]1[CH:8]=[CH:7][N:6]2[CH:9]=[C:10]([C:12]3[CH:13]=[C:14]([OH:18])[CH:15]=[CH:16][CH:17]=3)[N:11]=[C:5]2[N:4]=1.[C:19](OC(=O)C)(=[O:21])[CH3:20].N1C=CC=CC=1.C([O-])(O)=O.[Na+]>O>[NH2:2][C:3]1[CH:8]=[CH:7][N:6]2[CH:9]=[C:10]([C:12]3[CH:13]=[C:14]([O:18][C:19](=[O:21])[CH3:20])[CH:15]=[CH:16][CH:17]=3)[N:11]=[C:5]2[N:4]=1

Komponenten

6

Edukt 4

HCID 1049PyridineHCID 7918Acetic AnhydrideHCID 516892Sodium BicarbonateHCID 673879503-(7-Aminoimidazo[1,2-a]pyrimidin-2-yl)phenol hydrobromide

Produkt 1

HCID 58446806HCID 58446806, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
120 °C

Versuchsvorschrift

To a microwave vial were added 3-(7-aminoimidazo[1,2-a]pyrimidin-2-yl)phenol hydrobromide (500 mg, 1.63 mmol), acetic anhydride (199 mg, 185 μA, 1.95 mmol) and pyridine (5.00 ml). The vial was capped and heated in the microwave at 120° C. for 15 min. H2O was added to the reaction mixture and the pH was installed around 7-8 by addition of 10% NaHCO3 aq. solution. The product was extracted with CH2Cl2, then the solvent was partially evaporated and the formed solid was collected and purified by flash chromatography (SiO2 cartridge; eluent: CH2Cl2/MeOH/NH3aq. 140:10:1). White solid (207 mg, 45%).

Aufarbeitung

  1. customThe vial was capped
  2. extractionThe product was extracted with CH2Cl2
  3. customthe solvent was partially evaporated
  4. customthe formed solid was collected
  5. custompurified by flash chromatography (SiO2 cartridge; eluent: CH2Cl2/MeOH/NH3aq. 140:10:1)

Quellen und Nachweise

ORD-Eintrag
ord-23c58876ba114e87b7ab7047b3753644
Quelldatensatz
uspto-grants-2013_04
Patentnummer
US08410117B2

Notizen zur Reaktion

Wird geladen…