4-Fluoro-3-(trifluoromethyl)benzonitrile → 4-(Methylsulfonyl)-3-(trifluoromethyl)benzonitrile

HRID 1961427

Reaktionsgleichung

Reaktionsgleichung von HRID 1961427
F[C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][C:3]=1[C:10]([F:13])([F:12])[F:11].[CH3:14][S:15]([O-:17])=[O:16].[Na+]>CS(C)=O.O>[CH3:14][S:15]([C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][C:3]=1[C:10]([F:13])([F:12])[F:11])(=[O:17])=[O:16]

Komponenten

5

Edukt 2

HCID 1442554-Fluoro-3-(trifluoromethyl)benzonitrileHCID 2733271Sodium methanesulfinate

Produkt 1

HCID 459337164-(Methylsulfonyl)-3-(trifluoromethyl)benzonitrile

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 679Dimethyl SulfoxideLösungsmittelHCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

4-Fluoro-3-(trifluoromethyl)benzonitrile (400 mg, 2.12 mmol) was suspended together with sodium methanesulfinate (216 mg, 2.12 mmol) in DMSO (2 ml) and stirred at 80° C. for 22 hours. The reaction was then cooled, diluted with 25 ml H2O and filtered. Filtered solids were evaporated from toluene to give 536 mg of the title substance (quant).

Aufarbeitung

  1. temperatureThe reaction was then cooled
  2. filtrationfiltered
  3. filtrationFiltered solids
  4. customwere evaporated from toluene
  5. customto give 536 mg of the title substance (quant)

Quellen und Nachweise

ORD-Eintrag
ord-25131b47e8044a0abb5bb5e600f8a7d5
Quelldatensatz
uspto-grants-2013_04
Patentnummer
US08415333B2

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