Ethanol → 10,11-Dihydro-3-methoxy-8-methylthio-dibenzo[b,f]thiepin-10-ol

HRID 1973103Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1973103
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[CH2:12][C:11](=[O:13])[C:10]3[CH:14]=[C:15]([S:18][CH3:19])[CH:16]=[CH:17][C:9]=3[S:8][C:7]=2[CH:20]=1.C(O)C.[BH4-].[Na+]>O>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[CH2:12][CH:11]([OH:13])[C:10]3[CH:14]=[C:15]([S:18][CH3:19])[CH:16]=[CH:17][C:9]=3[S:8][C:7]=2[CH:20]=1

Komponenten

5

Edukt 3

HCID 702EthanolHCID 4311764Sodium borohydrideHCID 128221953-methoxy-8-methylthio-dibenzo[b,f]thiepin-10(11H)-one

Produkt 1

HCID 1282219810,11-Dihydro-3-methoxy-8-methylthio-dibenzo[b,f]thiepin-10-ol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

17.8 G. of 3-methoxy-8-methylthio-dibenzo[b,f]thiepin-10(11H)-one are suspended in 150 ml. of ethanol and treated with 3.8 g. of sodium borohydride. The mixture is stirred for 90 minutes. Then, it is treated with water and extracted with ether. The organic phase is washed with water, dried over magnesium sulfate, evaporated, and there is obtained 10,11-dihydro-3-methoxy-8-methylthio-dibenzo[b,f]thiepin-10-ol having a melting point of 122°-124° C.

Aufarbeitung

  1. extractionextracted with ether
  2. washThe organic phase is washed with water
  3. dry with materialdried over magnesium sulfate
  4. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-c1dec78aba7e49dda5666e2b32b88a19
Quelldatensatz
uspto-grants-1976_12
Patentnummer
US03996229

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