4-Amidinobenzamide Hydrochloride → HCID 13980725, Verbindung

HRID 1973586Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1973586
Cl.[C:2]([C:5]1[CH:13]=[CH:12][C:8]([C:9]([NH2:11])=O)=[CH:7][CH:6]=1)(=[NH:4])[NH2:3].[CH2:14]([C:20](=[CH:23]OCC)[CH:21]=O)[CH2:15][CH2:16][CH2:17][CH2:18][CH3:19].C[O-].[Na+].C(C1C=CN=C(C2C=CC(C(N)=O)=CC=2)N=1)CCCCC>CCOCC.CO>[CH2:14]([C:20]1[CH:21]=[N:3][C:2]([C:5]2[CH:13]=[CH:12][C:8]([C:9]#[N:11])=[CH:7][CH:6]=2)=[N:4][CH:23]=1)[CH2:15][CH2:16][CH2:17][CH2:18][CH3:19]

Komponenten

7

Edukt 4

HCID 27242934-Amidinobenzamide HydrochlorideHCID 10942334Sodium MethoxideHCID 541836714-(4-n-Hexylpyrimid-2-yl)benzoic acid amideHCID 542364922-n-Hexyl-3-ethoxy-acrolein

Produkt 1

HCID 13980725HCID 13980725, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

0.082 mol. of 4-amidino-benzoic acid amide hydrochloride, suspended in a solution of 0.082 mol. 2-n-hexyl-3-ethoxy-acrolein and 0.14 mol. of sodium methylate in 150 ml. of methanol, are stirred overnight under an atmosphere of nitrogen at room temperature. The precipitate obtained by dilution of the mixture with 3 liters of ether is removed by filtration, washed with water until neutral and dried at 40° C. in a vacuum drying cupboard, whereby there are obtained 17.9 g. of 4-(4-n-hexylpyrimid-2-yl)-benzoic acid amide; melting point 231.6°-233.0° C.

Aufarbeitung

  1. customis removed by filtration
  2. washwashed with water until neutral and
  3. customdried at 40° C. in a vacuum
  4. customdrying cupboard, whereby there
  5. customare obtained 17.9 g

Quellen und Nachweise

ORD-Eintrag
ord-e370640e25d64975bb8354ff9dc3b927
Quelldatensatz
uspto-grants-1976_12
Patentnummer
US03997536

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