[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]1[C:12](C)=[N:13][N:14]=[C:7]1[CH:6]=[C:5]2[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1.I([O-])(=O)(=O)=[O:23].[Na+]>CC(C)=O.O.[Ru](=O)=O>[Cl:1][C:2]1[CH:11]=[CH:10][C:9]([N:8]2[CH:12]=[N:13][N:14]=[C:7]2[CH3:6])=[C:4]([CH:3]=1)[C:5]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[O:23]
A stirred suspension of 7-chloro-1-methyl-5-phenyl-s-triazolo[4,3-a]quinoline (2.94 g., 0.01 mole) in acetone (110 ml.) is cooled in an ice-bath and treated slowly with a solution prepared by adding sodium periodate (2 g.) to a stirred suspension of ruthenium dioxide (200 mg.) in water (35 ml.). The mixture becomes dark. Additional sodium periodate (8 g.) is added during the next 15 minutes. The ice bath is removed and the mixture is stirred for 45 minutes. Additional sodium periodate (4 g.) is added and the mixture is stirred at ambient temperature for 18 hours and filtered. The solid is washed with acetone and the combined filtrate is concentrated in vacuo. The residue is suspended in water and extracted with methylene chloride. The extract is dried over anhydrous potassium carbonate and concentrated. The residue is chromatographed on silica gel (100 g.) with 10% methanol 90% ethyl acetate; 50 ml. fractions are collected. The product is eluted in fractions 10-20 and is crystallized from ethyl acetate to give: 0.405 g. of melting point 168°-169.5° C. and 0.291 g. of melting point 167.5°-169° (23.4% yield) of 5-chloro-2-(3-methyl-4H-1,2,4-triazol-4-yl)benzophenone. The analytical sample has a melting point of 168° C.
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