Diethyl Oxalate → Thieno[2,3-b]pyrazine-2,3(1H,4H)-dione
Reaktionsgleichung
[S:1]1[CH:5]=[CH:4][C:3]([NH:6][C:7](OC(C)(C)C)=[O:8])=[C:2]1[NH:14][C:15]([O:17]C(C)(C)C)=O.C(OCC)(=O)C(OCC)=O>C(O)(=O)C>[NH:6]1[C:7](=[O:8])[C:15](=[O:17])[NH:14][C:2]2[S:1][CH:5]=[CH:4][C:3]1=2Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
A mixture of di-t-butyl thiophene-2,3-dicarbamate (1.53 g, 4.87 mmol), diethyl oxalate (15 ml) and acetic acid (15 ml) was refluxed for 48 hours. The precipitate was filtered off, washed with water and dried to yield 0.64 g (78%) of the title compound. M.p. >340° C. 1H-NMR (DMSO-d6, δ): 6.74 (d, 1H), 7.13 (d, 1H), 12.28 (s, 1H).
Aufarbeitung
- temperaturewas refluxed for 48 hours
- filtrationThe precipitate was filtered off
- washwashed with water
- customdried
Quellen und Nachweise
- ORD-Eintrag
- ord-641f15be9ad14c66bd62c2230aecea1a
- Quelldatensatz
- uspto-grants-1994_02
- Patentnummer
- US05284847
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