Hydroxyamine hydrochloride → 2,4-Dichloro-3-cyano-5-fluorobenzoic acid

HRID 1976874Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1976874
Cl.[NH2:2]O.[Cl:4][C:5]1[C:13]([CH:14]=O)=[C:12]([Cl:16])[C:11]([F:17])=[CH:10][C:6]=1[C:7]([OH:9])=[O:8]>C(O)=O>[C:14]([C:13]1[C:5]([Cl:4])=[C:6]([CH:10]=[C:11]([F:17])[C:12]=1[Cl:16])[C:7]([OH:9])=[O:8])#[N:2]

Komponenten

4

Edukt 2

HCID 443297Hydroxyamine hydrochlorideHCID 186187622,4-Dichloro-5-fluoro-3-formylbenzoic acid

Produkt 1

HCID 109005412,4-Dichloro-3-cyano-5-fluorobenzoic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 284Formic AcidLösungsmittel

Reaktionsbedingungen

Temperatur
102.5 °C

Versuchsvorschrift

162 g of hydroxylamine hydrochloride were introduced into 2000 ml of formic acid (technical-grade, 85% strength). At 95° C., 950 g of 2,4-dichloro-5-fluoro-3-formylbenzoic acid (moistened with sulphuric acid, 42% strength) were introduced. As a result, the mixture foamed briefly and then a clear solution was immediately obtained. The mixture was then stirred for 4 hours at from 100 to 105° C. (reflux).

Aufarbeitung

  1. customa clear solution was immediately obtained

Quellen und Nachweise

ORD-Eintrag
ord-cbdbd7701598402b9c385c32f384bed0
Quelldatensatz
uspto-grants-2001_05
Patentnummer
US06229040B1

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