Sulfuryl chloride → 6-Chloro-7-methoxy-3,4-dihydrocarbostyril
Reaktionsgleichung
[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH2:7][CH2:8][C:9](=[O:13])[NH:10]2)=[CH:5][CH:4]=1.S(Cl)([Cl:17])(=O)=O>C(O)(=O)C>[Cl:17][C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][C:3]=1[O:2][CH3:1])[NH:10][C:9](=[O:13])[CH2:8][CH2:7]2Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
35.4 Grams of 7-methoxy-3,4-dihydrocarbostyril was dissolved in 300 ml of acetic acid and under ice-cooled condition with stirring 27 g of sulfuryl chloride dissolved in 100 ml of acetic acid was added dropwise, then the reaction mixture was allowed to stand overnight. The reaction mixture was poured into 1 liter of ice water and the precipitates were obtained by filtration, washed with water, dried and recrystallized from methanol. 30 Grams of 6-chloro-7-methoxy-3,4-dihydrocarbostyril having the melting point of 212° C. was obtained as in the form of colorless needle-like crystals.