Methane → HCID 20402691, Verbindung

HRID 1980262Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1980262
Cl.[NH2:2][C:3]1[C:4]([C:9](=[O:16])[C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[C:5]([CH3:8])[NH:6][CH:7]=1.C.[Cl:18][CH2:19][C:20](Cl)=[O:21].[OH-].[Na+]>O>[C:9]([C:4]1[C:3]([NH:2][C:20](=[O:21])[CH2:19][Cl:18])=[CH:7][NH:6][C:5]=1[CH3:8])(=[O:16])[C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1

Komponenten

6

Edukt 4

HCID 297MethaneHCID 6577Chloroacetyl chlorideHCID 14798Sodium HydroxideHCID 3042146Methanone, (4-amino-2-methyl-1H-pyrrol-3-yl)phenyl-, monohydrochloride

Produkt 1

HCID 20402691HCID 20402691, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

4-Amino-3-benzoyl-2-methylpyrrole hydrochloride (0.019 mole) was dissolved in water (40 ml) and the solution was treated with charcoal (0.1 g) and filtered. Toluene was added and chloroacetylchloride (0.067 mole) and aqueous NaOH (58.1 ml, 20% w/v) were added separately but simultaneously during 1 hour to the stirred two-phase solution. The reaction mixture was maintained under an inert atmosphere and at room temperature for 1.5 hour. The compound of the title which spontaneously crystallized out of the reaction mixture, was collected by filtration.

Aufarbeitung

  1. filtrationfiltered
  2. additionToluene was added
  3. customThe compound of the title which spontaneously crystallized out of the reaction mixture
  4. filtrationwas collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-501609bdceec4c06a5f8c4e9e7c1323c
Quelldatensatz
uspto-grants-1985_04
Patentnummer
US04508730

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