Acetone → 1-Ethyl-1-azabicyclo[2.2.2]octan-1-ium iodide

HRID 1980563

Reaktionsgleichung

Reaktionsgleichung von HRID 1980563
[N:1]12[CH2:8][CH2:7][CH:4]([CH2:5][CH2:6]1)[CH2:3][CH2:2]2.[CH2:9]([I:11])[CH3:10].CC(C)=O.C(OCC)C>C(Cl)(Cl)Cl>[I-:11].[CH2:9]([N+:1]12[CH2:8][CH2:7][CH:4]([CH2:5][CH2:6]1)[CH2:3][CH2:2]2)[CH3:10]

Komponenten

6

Edukt 4

HCID 180AcetoneHCID 3283Diethyl EtherHCID 6340IodoethaneHCID 7527Quinuclidine

Produkt 1

HCID 136522871-Ethyl-1-azabicyclo[2.2.2]octan-1-ium iodide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

20 grams of Quinuclidine (1 Aza bicyclo [2.2.2] octane, Aldrich) were dissolved in 100 ml of chloroform with stirring and cooling in an ice bath. 28.08 Grams of ethyl iodide (Aldrich) were added dropwise. The mixture became cloudy and was stirred overnight, slowly coming to room temperature. Acetone was added to the solution and then, with stirring, diethyl ether was added dropwise until crystals formed. The filtered solids were washed with acetone and dried under vacuum. The product had the correct microanalysis for C, H, and N.

Aufarbeitung

  1. temperaturecooling in an ice bath
  2. stirringwas stirred overnight
  3. customslowly coming to room temperature
  4. stirringwith stirring
  5. customformed
  6. washThe filtered solids were washed with acetone
  7. customdried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-27153fe7bd144b93a3bb0769607704a8
Quelldatensatz
uspto-grants-1985_04
Patentnummer
US04510256

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