Water → 1-Bromo-4-iodo-2-(phenoxymethyl)benzene

HRID 19820Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 19820
[C:1]1([OH:7])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Br:8][C:9]1[CH:14]=[CH:13][C:12]([I:15])=[CH:11][C:10]=1[CH2:16]Cl.[Na+].[I-].O>[OH-].[K+].CC(C)=O>[Br:8][C:9]1[CH:14]=[CH:13][C:12]([I:15])=[CH:11][C:10]=1[CH2:16][O:7][C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Komponenten

7

Edukt 4

HCID 962WaterHCID 996PhenolHCID 5238Sodium IodideHCID 593463281-Bromo-2-(chloromethyl)-4-iodobenzene

Produkt 1

HCID 593463231-Bromo-4-iodo-2-(phenoxymethyl)benzene

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 180AcetoneLösungsmittelHCID 14797Potassium HydroxideLösungsmittel

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

Phenol (13 g) dissolved in 4 M KOH solution (60 mL) is added to 4-bromo-3-chloromethyl-1-iodo-benzene (41.0 g) dissolved in acetone (50 mL). NaI (0.5 g) is added and the resulting mixture is stirred at 50° C. overnight. Then, water is added and the resulting mixture is extracted with ethyl acetate. The combined extracts are dried and the solvent is evaporated under reduced pressure. The residue is purified by chromatography on silica gel (cyclohexane/ethyl acetate 19:1).

Aufarbeitung

  1. extractionthe resulting mixture is extracted with ethyl acetate
  2. customThe combined extracts are dried
  3. customthe solvent is evaporated under reduced pressure
  4. customThe residue is purified by chromatography on silica gel (cyclohexane/ethyl acetate 19:1)

Quellen und Nachweise

ORD-Eintrag
ord-be65be81788d4d4daca27a46223d08e0
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07745414B2

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