Acetic Acid → 3-(3-fluorophenyl)-7-methoxy-1H-indazole-5-carboxylic acid

HRID 1983511Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1983511
[F:1][C:2]1[CH:3]=[C:4]([C:8]2[C:16]3[C:11](=[C:12]([O:19][CH3:20])[CH:13]=C(C#N)[CH:15]=3)[NH:10][N:9]=2)[CH:5]=[CH:6][CH:7]=1.[C:21]([OH:24])(=[O:23])[CH3:22].S(=O)(=O)(O)O>O>[F:1][C:2]1[CH:3]=[C:4]([C:8]2[C:16]3[C:11](=[C:12]([O:19][CH3:20])[CH:13]=[C:22]([C:21]([OH:24])=[O:23])[CH:15]=3)[NH:10][N:9]=2)[CH:5]=[CH:6][CH:7]=1

Komponenten

5

Edukt 3

HCID 176Acetic AcidHCID 1118Sulfuric AcidHCID 222608863-(3-fluorophenyl)-7-methoxy-1H-indazole-5-carbonitrile

Produkt 1

HCID 222607673-(3-fluorophenyl)-7-methoxy-1H-indazole-5-carboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel2×

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

To 450 mg of 3-(3-fluorophenyl)-7-methoxy-1H-indazole-5-carbonitrile were sequentially added 6 ml of glacial acetic acid, 2 ml of water and 2 ml of concentrated sulfuric acid, followed by stirring at 100° C. for one day. After standing to cool, water was added to the reaction mixture and the resulting crystals were collected by filtration. The crystals were sequentially washed with isopropanol and diethyl ether, to give 428 mg of the title compound as colorless crystals.

Aufarbeitung

  1. temperatureto cool
  2. filtrationthe resulting crystals were collected by filtration
  3. washThe crystals were sequentially washed with isopropanol and diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-484d83d48c5c4f2eb723b26b970546cc
Quelldatensatz
uspto-grants-2009_06
Patentnummer
US07541376B2

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