[S:1]1[C:5]([CH2:6][CH2:7][OH:8])=[CH:4][N:3]=[CH:2]1.[CH3:9][S:10](Cl)(=[O:12])=[O:11].CCN(CC)CC.O>C(Cl)Cl>[S:1]1[C:5]([CH2:6][CH2:7][O:8][S:10]([CH3:9])(=[O:12])=[O:11])=[CH:4][N:3]=[CH:2]1At 0° C., to a solution of 2-thiazol-5-yl-ethanol (0.154 g, 1.19 mmol) in CH2Cl2 (10 mL) was added MsCl (0.150 g, 1.31 mmol) and Et3N (0.180 g, 1.79 mmol). The mixture was stirred at room temperature for 1 h. Water (20 mL) was added, and the mixture was extracted with CH2Cl2 (3×30 mL). The extracts were combined and dried over Na2SO4. After filtration the solvent was removed by evaporation under vacuum, and the residue was purified by flash chromatography on a silica gel column (EtOAc), affording methanesulfonic acid 2-thiazol-5-yl-ethyl ester as a pale yellow liquid (0.246 g, 100%). 1H NMR(CDCl3) δ 2.99 (s, 3H), 3.33 (t, 2H, J=6.3 Hz), 4.42 (t, 2H, J=6.3 Hz), 7.73 (s, 1H), 8.74 (s, 1H).
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