Acetic Acid → HCID 68901947, Verbindung

HRID 1987701Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1987701
[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[C:10]1[S:11][CH:12]=[CH:13][CH:14]=1)([O-:3])=[O:2].[I:15]N1C(=O)CCC1=O.C(O)(=O)C>CO>[I:15][C:12]1[S:11][C:10]([C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N+:1]([O-:3])=[O:2])=[CH:14][CH:13]=1

Komponenten

5

Edukt 3

HCID 176Acetic AcidHCID 120273N-IodosuccinimideHCID 91672612-(2-nitrophenyl)thiophene

Produkt 1

HCID 68901947HCID 68901947, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

2-(2-nitro-phenyl)-thiophene (23 g, 0.11 mol) and N-iodosuccinimide (37 g, 0.165 mol) were dissolved in 110 ml of methanol. To this solution, acetic acid (10 g, 0.165 mol) was added. After stirring the reaction mixture for 4 hours at room temperature, the solvent was evaporated. The remainder was taken up in a mixture of ice and water and extracted with ethyl acetate. The combined organic layer was washed with saturated aqueous sodium hydrogencarbonate solution and brine, dried over magnesium sulfate and evaporated, delivering 2-iodo-5-(2-nitro-phenyl)-thiophene (28 g).

Aufarbeitung

  1. customthe solvent was evaporated
  2. additionThe remainder was taken up in a mixture of ice and water
  3. extractionextracted with ethyl acetate
  4. washThe combined organic layer was washed with saturated aqueous sodium hydrogencarbonate solution and brine
  5. dry with materialdried over magnesium sulfate
  6. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-abb13ff22a104882a68ed815deb540ba
Quelldatensatz
uspto-grants-2009_06
Patentnummer
US07553798B2

Notizen zur Reaktion

Wird geladen…