Pyridine → 2-Hydrazinyl-5-phenylpyrazine

HRID 1995061

Reaktionsgleichung

Reaktionsgleichung von HRID 1995061
Cl[C:2]1[CH:7]=[N:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[CH:4][N:3]=1.N1C=CC=CC=1.O.[NH2:21][NH2:22]>O>[NH:21]([C:2]1[CH:7]=[N:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[CH:4][N:3]=1)[NH2:22]

Komponenten

5

Edukt 3

HCID 1049PyridineHCID 24654Hydrazine hydrate (1:1)HCID 12366642-Chloro-5-phenylpyrazine

Produkt 1

HCID 131998672-Hydrazinyl-5-phenylpyrazine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A mixture of 1.0 g. of 2-chloro-5-phenylpyrazine, m.p. 98°-99° C., 5.0 ml. of pyridine and 5.0 ml. of hydrazine hydrate is heated at reflux for 1.5 hours. The solution is cooled, and 20 ml. of water is added. The colorless crystalline product is collected and air dried. The crude product is recrystallized from aqueous ethanol to yield 0.35 g. of the product of the example as colorless needles, m.p. 128°-130° C.

Aufarbeitung

  1. additionA mixture of 1.0 g
  2. temperatureat reflux for 1.5 hours
  3. temperatureThe solution is cooled
  4. customThe colorless crystalline product is collected
  5. customair dried
  6. customThe crude product is recrystallized from aqueous ethanol
  7. customto yield 0.35 g

Quellen und Nachweise

ORD-Eintrag
ord-21ffbdf0805c4b64b5feca5098d9f0ce
Quelldatensatz
uspto-grants-1983_09
Patentnummer
US04402958

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