Acetic Acid → HCID 178514957, Verbindung

HRID 1995840Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1995840
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([OH:8])[N:3]=1.[C:9]1(=O)[O:14][C:12](=[O:13])[C:11]2[CH2:15][CH2:16][CH2:17][CH2:18][C:10]1=2.C(O)(=O)C>C(Cl)(Cl)Cl>[OH:8][C:4]1[N:3]=[C:2]([N:1]2[C:12](=[O:13])[C:11]3[CH2:15][CH2:16][CH2:17][CH2:18][C:10]=3[C:9]2=[O:14])[CH:7]=[CH:6][CH:5]=1

Komponenten

5

Edukt 3

HCID 176Acetic AcidHCID 124753,4,5,6-Tetrahydrophthalic anhydrideHCID 1785076342-Amino-6-hydroxypyridine

Produkt 1

HCID 178514957HCID 178514957, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

A mixture of 2-amino-6-hydroxypyridine (2.2 g), 3,4,5,6-tetrahydrophthalic anhydride (3.0 g) and acetic acid (40 ml) is heated to reflux for about 18 hours. The reaction is then cooled and stripped. The concentrate is taken up in CHCl3 (100 ml), washed with water, dried and stripped to yield N-(6-hydroxy-2-pyridyl)-3,4,5,6-tetrahydrophthalimide.

Aufarbeitung

  1. temperatureis heated
  2. temperatureto reflux for about 18 hours
  3. temperatureThe reaction is then cooled
  4. washwashed with water
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-fecf112526254513bdfefa82450c79d8
Quelldatensatz
uspto-grants-1983_09
Patentnummer
US04406689

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