1-Bromo-3-methylbutane → 7-(3-Methylbutyl)-3-methylxanthine

HRID 2034

Reaktionsgleichung

Reaktionsgleichung von HRID 2034
[CH3:1][N:2]1[C:10]2[N:9]=[CH:8][NH:7][C:6]=2[C:5](=[O:11])[NH:4][C:3]1=[O:12].[H-].[Na+].[H][H].Br[CH2:18][CH2:19][CH:20]([CH3:22])[CH3:21]>CN(C=O)C.O>[CH3:21][CH:20]([CH3:22])[CH2:19][CH2:18][N:7]1[C:6]2[C:5](=[O:11])[NH:4][C:3](=[O:12])[N:2]([CH3:1])[C:10]=2[N:9]=[CH:8]1

Komponenten

7

Edukt 4

HCID 78911-Bromo-3-methylbutaneHCID 24758Sodium hydrideHCID 706393-MethylxanthineHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 196891447-(3-Methylbutyl)-3-methylxanthine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 6228DimethylformamideLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

100 g (0.602 mol) of 3-methylxanthine, dissolved in 1200 ml of DMF, were slowly treated with 16 g (0.66 mol) of sodium hydride. The solution was heated to 60° C. and, when the evolution of hydrogen was at an end, treated with 109 g (0.66 mol) of 1-bromo-3-methylbutane. The reaction mixture was stirred at 100° C. for 12 hours and introduced into 2000 ml of water. The precipitate was filtered off with suction, washed with water and dried to constant weight.

Aufarbeitung

  1. filtrationThe precipitate was filtered off with suction
  2. washwashed with water
  3. customdried to constant weight

Quellen und Nachweise

ORD-Eintrag
ord-53dbbec3515e46f1bf52497ce7ab8115
Quelldatensatz
uspto-grants-1998_03
Patentnummer
US05728686

Verknüpfte Notizen

Wird geladen…