2-Methoxyethanol → HCID 178496180, Verbindung

HRID 2042820Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2042820
[CH3:1][O:2][CH2:3][CH2:4][OH:5].CC([O-])(C)C.[K+].Cl[C:13]1[N:31]=[C:30]([Cl:32])[CH:29]=[CH:28][C:14]=1[C:15]([NH:17][C@H:18]1[CH2:23][CH2:22][C@H:21]([C:24]([F:27])([F:26])[F:25])[CH2:20][CH2:19]1)=[O:16]>C1COCC1.O>[Cl:32][C:30]1[CH:29]=[CH:28][C:14]([C:15]([NH:17][C@H:18]2[CH2:23][CH2:22][C@H:21]([C:24]([F:27])([F:26])[F:25])[CH2:20][CH2:19]2)=[O:16])=[C:13]([O:5][CH2:4][CH2:3][O:2][CH3:1])[N:31]=1

Komponenten

6

Edukt 3

HCID 80192-MethoxyethanolHCID 23665647Potassium tert-butoxideHCID 178523747HCID 178523747, Verbindung

Produkt 1

HCID 178496180HCID 178496180, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

2-Methoxyethanol (550 μL, 6.94 mmol) is added at rt to KOtBu (750 mg, 6.35 mmol) in THF (30 mL) and it is stirred for 5 min. 2,6-Dichloro-N-(trans-4-trifluoromethyl-cyclohexyl)-nicotinamide (2.00 g, 5.86 mmol) is added to the reaction mixture and it is stirred for 10 min at rt. The reaction mixture is diluted with water, filtered and the filtrate is concentrated. The residue is treated with water, filtered off, washed with water and dried.

Aufarbeitung

  1. stirringis stirred for 10 min at rt
  2. filtrationfiltered
  3. concentrationthe filtrate is concentrated
  4. additionThe residue is treated with water
  5. filtrationfiltered off
  6. washwashed with water
  7. customdried

Quellen und Nachweise

ORD-Eintrag
ord-043e2677ff7045c3a922bf56bde1255e
Quelldatensatz
uspto-grants-2013_11
Patentnummer
US08586604B2

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