Water → 2-amino-7-(4-chlorophenyl)-7,8-dihydroquinazolin-5(6H)-one

HRID 2046451Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2046451
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:13][C:12](=O)[C:11](=[CH:15]N(C)C)[C:10](=[O:19])[CH2:9]2)=[CH:4][CH:3]=1.Cl.[NH2:21][C:22]([NH2:24])=[NH:23].C(=O)([O-])[O-].[Na+].[Na+].O>C(O)C>[NH2:23][C:22]1[N:24]=[CH:15][C:11]2[C:10](=[O:19])[CH2:9][CH:8]([C:5]3[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=3)[CH2:13][C:12]=2[N:21]=1

Komponenten

6

Edukt 4

HCID 962WaterHCID 5742Guanidine HydrochlorideHCID 10340Sodium CarbonateHCID 5670705-(4-Chlorophenyl)-2-[(dimethylamino)methylene]-1,3-cyclohexanedione

Produkt 1

HCID 27723712-amino-7-(4-chlorophenyl)-7,8-dihydroquinazolin-5(6H)-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

5-(4-Chloro-phenyl)-2-dimethylaminomethylene-cyclohexane-1,3-dione (0.8 g, 2.89 mmol) from stage 1, guanidine hydrochloride (551 mg, 5.77 mmol) and sodium carbonate (919 mg, 8.67 mmol) were stirred in ethanol (10 ml) at reflux for 4 h. The reaction mixture was cooled to ambient temperature and water (10 ml) was added to the flask. The resulting precipitate was recovered by filtration, washed with water (15 ml), heptane (15 ml) and air dried.

Aufarbeitung

  1. temperatureat reflux for 4 h
  2. filtrationThe resulting precipitate was recovered by filtration
  3. washwashed with water (15 ml), heptane (15 ml) and air
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-e209105160994304acc27b198ef271aa
Quelldatensatz
uspto-grants-2013_11
Patentnummer
US08592430B2

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