Acetic Acid → (2-Acetamido-3-benzoylphenyl)acetic acid

HRID 2051863Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2051863
[CH3:1][C:2]1[NH:3][C:4]2[C:9]([C:10]=1[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[CH:8][CH:7]=[CH:6][C:5]=2[CH2:17][C:18]([OH:20])=[O:19].C(O)(=[O:23])C.O=[O+][O-].[OH2:28]>>[C:2]([NH:3][C:4]1[C:9]([C:10](=[O:23])[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:8][CH:7]=[CH:6][C:5]=1[CH2:17][C:18]([OH:20])=[O:19])(=[O:28])[CH3:1]

Komponenten

5

Edukt 4

HCID 176Acetic AcidHCID 962WaterHCID 24823OzoneHCID 20378312(2-Methyl-3-phenyl-1H-indol-7-yl)acetic acid

Produkt 1

HCID 15634767(2-Acetamido-3-benzoylphenyl)acetic acid

Versuchsvorschrift

A solution of 2 g. of α-(2-methyl-3-phenylindol-7-yl)acetic acid in 60 ml. of acetic acid was treated with ozone for 15 minutes. The reaction mixture was treated with 10 ml. of water and allowed to evaporate overnight. The residue (1.7 g.) was recrystallized from isopropanol; yield 1.6 g. (71%); m.p. 188°-190° C.

Aufarbeitung

  1. additionThe reaction mixture was treated with 10 ml
  2. customto evaporate overnight
  3. customThe residue (1.7 g.) was recrystallized from isopropanol

Quellen und Nachweise

ORD-Eintrag
ord-43e3714388b94dd393db0ad627546bd2
Quelldatensatz
uspto-grants-1980_01
Patentnummer
US04182774

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