Pyridine → 4-Acetamido-2-bromo-thiazole

HRID 2052210Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2052210
Br.[NH2:2][C:3]1[N:4]=[C:5]([Br:8])[S:6][CH:7]=1.N1C=CC=CC=1.[C:15]([O-])(=[O:17])[CH3:16].[Na+]>C(OC(=O)C)(=O)C>[C:15]([NH:2][C:3]1[N:4]=[C:5]([Br:8])[S:6][CH:7]=1)(=[O:17])[CH3:16]

Komponenten

5

Edukt 3

HCID 1049PyridineHCID 517045Sodium AcetateHCID 202940412-Bromo-1,3-thiazol-4-amine--hydrogen bromide (1/1)

Produkt 1

HCID 202940434-Acetamido-2-bromo-thiazoleAusbeute 80 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 7918Acetic AnhydrideLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

4-Amino-2-bromothiazole hydrobromide (52 g, 0.2 m) was suspended in acetic anhydride (200 ml) then treated dropwise with pyridine (100 ml), maintaining the temperature at 0° C. by means of an ice bath. After the addition was complete, the reaction mixture was stirred for 2 h. at room temperature then poured onto 20% aqueous sodium acetate (2 l.). The solution was cooled, filtered and the precipitate washed with water (2×200 ml.). The product was air dried and recrystallised from acetone to give the title compound (35 g, 80%) m.p. 165° C.

Aufarbeitung

  1. additionAfter the addition
  2. temperatureThe solution was cooled
  3. filtrationfiltered
  4. washthe precipitate washed with water (2×200 ml.)
  5. customdried
  6. customrecrystallised from acetone

Quellen und Nachweise

ORD-Eintrag
ord-893f7210ef4e4c298c529d6ff2c2da18
Quelldatensatz
uspto-grants-1980_01
Patentnummer
US04183854

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