Hydrochloric Acid → {4-[2-(4-Fluorophenyl)ethyl]piperazin-1-yl}isoquinolin-1-ylmethanone, hydrochloride

HRID 2054693

Reaktionsgleichung

Reaktionsgleichung von HRID 2054693
[ClH:1].[F:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH2:10][N:11]2[CH2:16][CH2:15][N:14]([C:17]([C:19]3[C:28]4[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=4)[CH:22]=[CH:21][N:20]=3)=[O:18])[CH2:13][CH2:12]2)=[CH:5][CH:4]=1>CC(C)=O.CCOCC>[ClH:1].[F:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH2:10][N:11]2[CH2:16][CH2:15][N:14]([C:17]([C:19]3[C:28]4[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=4)[CH:22]=[CH:21][N:20]=3)=[O:18])[CH2:13][CH2:12]2)=[CH:5][CH:4]=1

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 9885359{4-[2-(4-Fluorophenyl)ethyl]piperazin-1-yl}isoquinolin-1-ylmethanone

Produkt 1

HCID 131726767{4-[2-(4-Fluorophenyl)ethyl]piperazin-1-yl}isoquinolin-1-ylmethanone, hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 180AcetoneLösungsmittelHCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

For salt formation, 1N hydrochloric acid is added to a solution of {4-[2-(4-fluorophenyl)ethyl]piperazin-1-yl}isoquinolin-1-ylmethanone in 60 ml of acetone and 50 ml of ether until crystals form. When crystallisation is complete, the mother liquor is filtered off, and the precipitate is washed with ether and dried, giving {4-[2-(4-fluorophenyl)ethyl]piperazin-1-yl}isoquinolin-1-ylmethanone, hydrochloride, m.p. 238-240°.

Aufarbeitung

  1. customform
  2. customWhen crystallisation
  3. filtrationthe mother liquor is filtered off
  4. washthe precipitate is washed with ether
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-d0a23f68871b41f4a282286bf96a4ab9
Quelldatensatz
uspto-grants-2008_02
Patentnummer
US07329749B2

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