Hydroxylamine → HCID 178495721, Verbindung
Reaktionsgleichung
[NH2:1][OH:2].[C:3]([C:5]1[CH:32]=[CH:31][C:8]([O:9][C:10]2[CH:11]=[C:12]([CH:22]=[C:23]([O:25][C@@H:26]([CH3:30])[CH2:27][O:28][CH3:29])[CH:24]=2)[C:13]([NH:15][C:16]2[CH:20]=[CH:19][N:18]([CH3:21])[N:17]=2)=[O:14])=[CH:7][CH:6]=1)#[N:4]>C(O)C>[OH:2][NH:1][C:3](=[NH:4])[C:5]1[CH:32]=[CH:31][C:8]([O:9][C:10]2[CH:11]=[C:12]([CH:22]=[C:23]([O:25][C@@H:26]([CH3:30])[CH2:27][O:28][CH3:29])[CH:24]=2)[C:13]([NH:15][C:16]2[CH:20]=[CH:19][N:18]([CH3:21])[N:17]=2)=[O:14])=[CH:7][CH:6]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
Hydroxylamine (50% w/w solution, 1 mL) was added to absolution of 3-(4-cyanophenoxy)-5-[(1S)-2-methoxy-(1-methylethyl)oxy]-N-(1-methyl-1H-pyrazol-3-yl)benzamide (300 mg, 0.74 mmol) in ethanol (3 mL) and the reaction mixture allowed to stir at RT for 18 hours. The volatiles were removed in vacuo to give the desired compound as a colourless foam (325 mg).