Acetic Anhydride → N-(5-Chloro-2-methoxyphenyl)acetamide

HRID 2057572

Reaktionsgleichung

Reaktionsgleichung von HRID 2057572
[NH2:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[O:9][CH3:10].[C:11](OC(=O)C)(=[O:13])[CH3:12]>[Zn]>[C:11]([NH:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[O:9][CH3:10])(=[O:13])[CH3:12]

Komponenten

4

Edukt 2

HCID 7918Acetic AnhydrideHCID 667635-Chloro-2-methoxyaniline

Produkt 1

HCID 346203N-(5-Chloro-2-methoxyphenyl)acetamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 23994ZincKatalysator

Versuchsvorschrift

0.2 mol (31.5 g) of 2-amino-4-chloroanisole, 40 ml of absolute alcohol, 20 ml of acetic anhydride and a pinch of zinc powder are placed in a 150 ml flask; the solution is brought to reflux for 30 minutes. The reaction liquid is poured onto crushed ice. The product obtained is separated; it is crystallized in a methanol/water mixture (20/80).

Aufarbeitung

  1. temperatureto reflux for 30 minutes
  2. customThe reaction liquid
  3. additionis poured
  4. customonto crushed ice
  5. customThe product obtained
  6. customis separated
  7. customit is crystallized in a methanol/water mixture (20/80)

Quellen und Nachweise

ORD-Eintrag
ord-c42d966b02af44adb9dfab5d9b71aeeb
Quelldatensatz
uspto-grants-1980_07
Patentnummer
US04211776

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