3-Methoxy-3-oxopropanoic acid → HCID 178500105, Verbindung

HRID 2059480Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2059480
COC(=O)CC(=O)O.COc1ccc2c(c1)c(CC=O)c(C)n2C(=O)c1ccc(Cl)cc1>C1COCCN1.CN(C)c1ccncc1.C1CCOC1>COC(=O)/C=C/Cc1c(C)n(C(=O)c2ccc(Cl)cc2)c2ccc(OC)cc12

Komponenten

6

Edukt 2

HCID 5383663-Methoxy-3-oxopropanoic acidHCID 20158193[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetaldehyde

Produkt 1

HCID 178500105HCID 178500105, VerbindungAusbeute 80 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 142844-(Dimethylamino)pyridineReagenzHCID 8083MorpholineKatalysatorHCID 8028TetrahydrofuranLösungsmittel

Reaktionsbedingungen

Temperatur
50 °C

Aufarbeitung

  1. temperatureThe product mixture was cooled to 25 °C.
  2. filtrationFiltered through a pad of celite · Organic-Phase beibehalten
  3. wash"The celite was washed with ethyl acetate (3 x 1 mL)."
  4. concentrationThe filtrate was concentrated under reduced pressure
  5. additionA 0.07 M stock solution of the internal standard ethylene carbonate (0.70 mL in CDCl3) was added.

Quellen und Nachweise

ORD-Eintrag
ord-9e531918475e43bb95313495bd1ca7a6
Quelldatensatz
Transfer learning optimization of 26 decarboxylative olefination reactions

Notizen zur Reaktion

Wird geladen…