Hydrochloric Acid → 2-Methoxyphenylboronic acid

n-Butyl lithium (13.0 ml of a 1.6M solution in hexanes, 19.8 mmol) was added dropwise to a solution of 2-bromoanisole (3.74 g, 19.0 mmol) in anhydrous tetrahydrofuran (15 ml) cooled to below -70° C., maintaining the temperature during the addition below -60° C. The solution was stirred for 20 minutes before the addition of trimethyl borate (5.9 ml, 57.0 mmol), and then stirred at below -70° C. for a further hour before warming to room temperature overnight. The reaction mixture was cooled to 0° C. acidified to pH 5.0 with 5% aqueous hydrochloric acid solution (25 ml), the resulting layers separated and the aqueous phase extracted with ethyl acetate (2×25 ml). The combined orgnic layers were washed with brine (25 ml), dried (MgSO4) and concentrated in vacuo to yield the title compound as a white solid (2.9 g, 97%) which was used without further purification.

1. temperaturecooled to below -70° C.
2. temperaturemaintaining the temperature
3. additionduring the addition below -60° C
4. temperatureThe reaction mixture was cooled to 0° C.
5. customthe resulting layers separated
6. extractionthe aqueous phase extracted with ethyl acetate (2×25 ml)
7. washThe combined orgnic layers were washed with brine (25 ml)
8. dry with materialdried (MgSO4)
9. concentrationconcentrated in vacuo

ORD-Eintrag

ord-2a3e93aba57f445fa9497b301fde8efd

Quelldatensatz

uspto-grants-1998_03

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US05728695