Sulfamide → HCID 11492439, Verbindung

HRID 2061904Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2061904
[CH3:1][C:2]1[O:3][C:4]2[CH:12]=[CH:11][CH:10]=[CH:9][C:5]=2[C:6]=1[CH:7]=O.[S:13]([NH2:17])([NH2:16])(=[O:15])=[O:14].[BH4-].[Na+]>C(O)C.O>[CH3:1][C:2]1[O:3][C:4]2[CH:12]=[CH:11][CH:10]=[CH:9][C:5]=2[C:6]=1[CH2:7][NH:16][S:13]([NH2:17])(=[O:15])=[O:14]

Komponenten

6

Edukt 3

HCID 82267SulfamideHCID 5944592-Methylbenzofuran-3-carbaldehydeHCID 4311764Sodium borohydride

Produkt 1

HCID 11492439HCID 11492439, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

2-Methylbenzofuran-3-carbaldehyde (0.51 g, 3.18 mmol) was dissolved in anhydrous ethanol (25 mL). Sulfamide (1.5 g, 16 mmol) was added and the mixture was heated to reflux for 4 days. The mixture was cooled to room temperature. Sodium borohydride (0.132 g, 3.50 mmol) was added and the mixture was stirred at room temperature for 24 hours. The reaction was diluted with water (100 mL) and extracted with DCM (3×75 mL). The extracts were concentrated and suspended in a minimal amount of DCM and filtered to yield the title compound as a white solid.

Aufarbeitung

  1. temperaturethe mixture was heated
  2. temperatureto reflux for 4 days
  3. extractionextracted with DCM (3×75 mL)
  4. concentrationThe extracts were concentrated
  5. filtrationfiltered

Quellen und Nachweise

ORD-Eintrag
ord-cdfee2381cee4727a5d5804bb3142b73
Quelldatensatz
uspto-grants-2012_10
Patentnummer
US08283478B2

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