1,2-Dichloroethane → (5-Chlorocarbonyl-pyridin-2-yl)-methyl-carbamic acid tert-butyl ester

HRID 2063270Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2063270
[C:1]([O:5][C:6]([N:8]([CH3:18])[C:9]1[CH:17]=[CH:16][C:12]([C:13](O)=[O:14])=[CH:11][N:10]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].CN.C(N)C.[Cl:24]CCCl>>[C:1]([O:5][C:6](=[O:7])[N:8]([C:9]1[CH:17]=[CH:16][C:12]([C:13]([Cl:24])=[O:14])=[CH:11][N:10]=1)[CH3:18])([CH3:4])([CH3:3])[CH3:2]

Komponenten

5

Edukt 4

HCID 111,2-DichloroethaneHCID 6329MethylamineHCID 6341EthylamineHCID 667695966-((tert-Butoxycarbonyl)(methyl)amino)nicotinic acid

Produkt 1

HCID 86664608(5-Chlorocarbonyl-pyridin-2-yl)-methyl-carbamic acid tert-butyl ester

Versuchsvorschrift

6-(tert-Butoxycarbonyl-methyl-amino)-nicotinic acid (12.5 g, 47.0 mmol) [prepared analogously to A-05 using methylamine in stead of ethylamine] is taken up in 300 mL DCE, 1-chloro-N,N-2-trimethylpropenyl-amine (10.0 mL, 74.8 mmol) is added and the reaction mixture is stirred overnight at RT. The reaction mixture is concentrated under reduced pressure and the crude product is used in the next step without purification.

Aufarbeitung

  1. concentrationThe reaction mixture is concentrated under reduced pressure
  2. customthe crude product is used in the next step without purification

Quellen und Nachweise

ORD-Eintrag
ord-e8c22a70c07443e499cf9bd59d47ddc2
Quelldatensatz
uspto-grants-2012_10
Patentnummer
US08288379B2

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