N,N-Dimethylaniline → HCID 25259881, Verbindung

HRID 2064569

Reaktionsgleichung

Reaktionsgleichung von HRID 2064569
[F:1][C:2]([F:25])([F:24])[C:3]1[CH:4]=[C:5]([CH:9]([O:13][C:14]2[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=CN=2)[C:10]([OH:12])=[O:11])[CH:6]=[CH:7][CH:8]=1.[CH3:26][N:27](C)C1C=CC=CC=1.O1[CH2:40][CH2:39][N:38]([CH:41](O)[CH3:42])[CH2:37][CH2:36]1.[OH2:44]>O1CCCC1.CCOCC>[N:38]1([CH2:41][CH2:42][O:12][C:10](=[O:11])[CH:9]([C:5]2[CH:6]=[CH:7][CH:8]=[C:3]([C:2]([F:1])([F:25])[F:24])[CH:4]=2)[O:13][C:14]2[CH:26]=[N:27][C:17]([C:20]([F:21])([F:22])[F:23])=[CH:18][CH:19]=2)[CH2:39][CH2:40][O:44][CH2:36][CH2:37]1

Komponenten

7

Edukt 4

HCID 949N,N-DimethylanilineHCID 962WaterHCID 30293761-MorpholinoethanolHCID 25259649HCID 25259649, Verbindung

Produkt 1

HCID 25259881HCID 25259881, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 3283Diethyl EtherLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

(3-Trifluoromethyl-phenyl)-(5-trifluoromethyl-pyridin-2-yloxy)-acetic acid, 100, prepared as described in Example 4, (0.05 mol) was converted into the acid chloride, using the procedure of Example 6. The acid chloride (0.01 mol) was dissolved in tetrahydrofuran (25 mL) and N,N-dimethylaniline (2 mL) and morpholinoethanol (2 mL) were added. The progress of the reaction was monitored by TLC. When the reaction was complete, water and ether were added. The organic phase was washed with dilute hydrochloric acid, dried and concentrated. The residue was chromatographed to afford the title compound 137.

Aufarbeitung

  1. washThe organic phase was washed with dilute hydrochloric acid
  2. customdried
  3. concentrationconcentrated
  4. customThe residue was chromatographed

Quellen und Nachweise

ORD-Eintrag
ord-a5e56f69397041739a93f9299d13f4f5
Quelldatensatz
uspto-grants-2012_10
Patentnummer
US08288438B2

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