Formic Acid → HCID 178422326, Verbindung

HRID 2064634Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2064634
[Cl:1][C:2]1[C:3]([CH3:10])=[CH:4][C:5]([NH2:9])=[C:6]([NH2:8])[CH:7]=1.[OH-].[NH4+].[CH:13](O)=O>Cl>[Cl:1][C:2]1[C:3]([CH3:10])=[CH:4][C:5]2[N:9]=[CH:13][NH:8][C:6]=2[CH:7]=1

Komponenten

5

Edukt 3

HCID 284Formic AcidHCID 14923Ammonium HydroxideHCID 28014684-Chloro-5-methylbenzene-1,2-diamine

Produkt 1

HCID 178422326HCID 178422326, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 313Hydrochloric AcidLösungsmittel

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

A solution of 5-chloro-4-methyl-1,2-phenylenediamine (7.8 g) in a mixture of formic acid (35 mL) and hydrochloric acid (300 mL) was heated at 50° C. for 3 hours then treated with ammonium hydroxide solution until the solution was basic. The reaction mixture was then extracted with dichloromethane. The extracts were evaporated to give 6-chloro-5-methyl-1H-benzoimidazole (7 g).

Aufarbeitung

  1. extractionThe reaction mixture was then extracted with dichloromethane
  2. customThe extracts were evaporated

Quellen und Nachweise

ORD-Eintrag
ord-268aecd43ad9496d950dfeba1e7333ae
Quelldatensatz
uspto-grants-2012_10
Patentnummer
US08288425B2

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