6-Chloroimidazo[2,1-b][1,3]thiazole-5-carbaldehyde → 6-Chloroimidazo[2,1-b][1,3]thiazole-5-carboxylic acid

HRID 2064749Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2064749
[O-:1]Cl.[Na+].[Cl:4][C:5]1[N:6]=[C:7]2[N:11]([C:12]=1[CH:13]=[O:14])[CH:10]=[CH:9][S:8]2>O.C(O)(C)(C)C>[Cl:4][C:5]1[N:6]=[C:7]2[N:11]([C:12]=1[C:13]([OH:1])=[O:14])[CH:10]=[CH:9][S:8]2

Komponenten

5

Edukt 2

HCID 3299506-Chloroimidazo[2,1-b][1,3]thiazole-5-carbaldehydeHCID 23665760Sodium Hypochlorite

Produkt 1

HCID 3299776-Chloroimidazo[2,1-b][1,3]thiazole-5-carboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 6386tert-ButanolLösungsmittel

Versuchsvorschrift

A solution of NaOCl (230 mmol) and NaH2PO4 (176 mmol) in water (195 mL) is added dropwise to a solution of 6-chloro-imidazo[2,1-b]thiazole-5-carbaldehyde (26.8 mmol) in tert.-butanol (195 mL) and the mixture is stirred for 8 h at RT. The solvents are partially removed in vacuo and the obtained precipitate is filtered off. The filtrate is made acidic and the obtained precipitate is filtered off to give the desired product as a white solid. LC-MS: tR=0.67 min; [M+H]+=202.9.

Aufarbeitung

  1. customThe solvents are partially removed in vacuo
  2. filtrationthe obtained precipitate is filtered off
  3. filtrationthe obtained precipitate is filtered off

Quellen und Nachweise

ORD-Eintrag
ord-f8a3397c310d4681ac1b2a38b5f3b71a
Quelldatensatz
uspto-grants-2012_10
Patentnummer
US08288435B2

Notizen zur Reaktion

Wird geladen…