Nitrogen → Methanesulfonic acid 4-acetyl-oxazol-2-ylmethyl ester

Temperatur

0 °C

In a flame dried round-bottomed flask equipped with a magnetic stir bar and under inert atmosphere (N2), a solution of 1-(2-hydroxymethyl-oxazol-4-yl)-ethanone (45 mg, 0.32 mmol) in dry CH2Cl2 (5.0 mL) was treated at 0° C. with Et3N (0.06 mL, 0.41 mmol) followed by DMAP (3.9 mg, 0.03 mmol) and Ms-Cl (0.03 mL, 0.40 mmol). After stirring at 0° C. for 30 min, the reaction mixture was quenched with water (10 mL), extracted with CH2Cl2 (10 mL) and the combined org. extracts were dried over Na2SO4, filtered, and the solvents were removed under reduced pressure to give the title compound as a yellow oil. TLC: rf (EA)=0.63. LC-MS-conditions 02: tR=0.64 min; [M+H]+=220.22.

1. customthe reaction mixture was quenched with water (10 mL)
2. extractionextracted with CH2Cl2 (10 mL)
3. dry with materialextracts were dried over Na2SO4
4. filtrationfiltered
5. customthe solvents were removed under reduced pressure

ORD-Eintrag

ord-a1e6cbb219db43a19b5bcb92a8eb0b4e

Quelldatensatz

uspto-grants-2012_10

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08288419B2