Tetrahydrofuran → 1-Methyl-4-{5-[2-(2,2,6,6-tetramethyl-piperidin-4-ylamino)-pyrimidin-4-yl]-thiophen-2-yl}-piperidin-4-ol
Reaktionsgleichung
[Br:1][c:2]1[cH:3][cH:4][c:5](-[c:7]2[n:8][c:9]([NH:13][CH:14]3[CH2:15][C:16]([CH3:22])([CH3:23])[NH:17][C:18]([CH3:20])([CH3:21])[CH2:19]3)[n:10][cH:11][cH:12]2)[s:6]1.[CH2:37]1[O:38][CH2:39][CH2:40][CH2:41]1.[CH3:24][CH2:25][CH2:26][CH2:27][Li:28].[CH3:29][N:30]1[CH2:31][CH2:32][C:33](=[O:36])[CH2:34][CH2:35]1>>[c:2]1([C:33]2([OH:36])[CH2:32][CH2:31][N:30]([CH3:29])[CH2:35][CH2:34]2)[cH:3][cH:4][c:5](-[c:7]2[n:8][c:9]([NH:13][CH:14]3[CH2:15][C:16]([CH3:22])([CH3:23])[NH:17][C:18]([CH3:20])([CH3:21])[CH2:19]3)[n:10][cH:11][cH:12]2)[s:6]1Komponenten
5
