Potassium Carbonate → Ethyl 3-[1-(4-methyl-2-nitrophenyl)-1H-imidazol-2-yl]-propanoate

HRID 2068982Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2068982
F[C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10].[NH:12]1[CH:16]=[CH:15][N:14]=[C:13]1[CH2:17][CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20].C(=O)([O-])[O-].[K+].[K+].CN(C)C(=O)C>C(OCC)C>[CH3:8][C:5]1[CH:6]=[CH:7][C:2]([N:12]2[CH:16]=[CH:15][N:14]=[C:13]2[CH2:17][CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])=[C:3]([N+:9]([O-:11])=[O:10])[CH:4]=1

Komponenten

6

Edukt 4

HCID 11430Potassium CarbonateHCID 31374DimethylacetamideHCID 1362874-Fluoro-3-nitrotolueneHCID 22259341Ethyl 3-(1H-imidazol-2-YL)propanoate

Produkt 1

HCID 59198588Ethyl 3-[1-(4-methyl-2-nitrophenyl)-1H-imidazol-2-yl]-propanoateAusbeute 92,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

1-Fluoro-4-methyl-2-nitrobenzene 239 mg, ethyl 3-(1H-imidazol-2-yl)propanoate 252 mg, potassium carbonate 415 mg and N,N-dimethylacetamide 10 mL were stirred at 100° C. for 11.5 hours, and then at 130° C., for 6 hours. The reaction liquid was diluted with diethyl ether, washed with water and saturated brine by the order stated, and dried over magnesium sulfate. Distilling the solvent off under reduced pressure, the residue was subjected to silica gel chromatography (ethyl acetate) to provide 422 mg of the title compound.

Aufarbeitung

  1. customThe reaction liquid
  2. washwashed with water and saturated brine by the order
  3. dry with materialdried over magnesium sulfate
  4. distillationDistilling the solvent off under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-f7f379cde3d74360a4b893aa57b67f9c
Quelldatensatz
uspto-grants-2012_10
Patentnummer
US08299080B2

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