Dimethylformamide → 4-(Trifluoromethyl)pyridine-2-carbaldehyde

Temperatur

-78 °C

To 2-bromo-4-(trifluoromethyl)pyridine (700 mg, 3.1 mmol) in ether (30 ml) at −78° C., BuLi (1.6M in hexanes, 2.13 ml) was added. After 40 min, DMF (340 mg) was added and the reaction mixture was stirred at −78° C. for a further 45 minutes and the reaction mixture was allowed to come to rt over a period of 1 h. Then the reaction mixture was quenched with solid ammonium chloride and partitioned between water and ether. Organic layers were dried and evaporated to provide 4-(trifluoromethyl)picolinaldehyde as a crude residue which was carried to the next step without further purification.

1. waitto come to rt over a period of 1 h
2. customThen the reaction mixture was quenched with solid ammonium chloride
3. custompartitioned between water and ether
4. customOrganic layers were dried
5. customevaporated

ORD-Eintrag

ord-7e1bf1bd0fb64035859c6490de490d03

Quelldatensatz

uspto-grants-2012_10

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08299267B2