Ethanol → 3-Methyl-8-oximino-5,6,7,8-tetrahydroquinoline
Reaktionsgleichung
[CH3:1][C:2]1[CH:3]=[N:4][C:5]2[C:6](=O)[CH2:7][CH2:8][CH2:9][C:10]=2[CH:11]=1.Cl.[NH2:14][OH:15].[OH-].[Na+].C(O)C>O>[CH3:1][C:2]1[CH:3]=[N:4][C:5]2[C:6](=[N:14][OH:15])[CH2:7][CH2:8][CH2:9][C:10]=2[CH:11]=1Komponenten
6
Edukt 4
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
The quinoline (30g), hydroxylamine hydrochloride (14g), sodium hydroxide (9g), ethanol (165ml) and water (65ml) were stirred and refluxed for 2 hours. Water (100ml) was added and the product was allowed to crystallise overnight. The crystals were removed by filtration and washed with water and dried to give 3-methyl-8-oximino-5,6,7,8-tetrahydroquinoline (27.5g) mp 188° C.
Aufarbeitung
- temperaturerefluxed for 2 hours
- customto crystallise overnight
- customThe crystals were removed by filtration
- washwashed with water
- customdried
Quellen und Nachweise
- ORD-Eintrag
- ord-bad60323c8ff471fa2c71be304bfaeb8
- Quelldatensatz
- uspto-grants-1977_09
- Patentnummer
- US04048175
Notizen zur Reaktion
Wird geladen…