Ethanol → HCID 19858041, Verbindung

HRID 2073396Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2073396
[CH3:1][C:2]1([CH3:24])[C:6](=[O:7])[O:5][C:4]2[CH:8]=[CH:9][C:10]3[C:15]([C:3]1=2)=[CH:14][C:13]([CH2:16][N:17]1[CH:21]=[N:20][CH:19]=[N:18]1)=[C:12]([C:22]#[N:23])[CH:11]=3.C(O)C.[BH4-].[Na+]>O>[OH:7][CH:6]1[O:5][C:4]2[CH:8]=[CH:9][C:10]3[C:15]([C:3]=2[C:2]1([CH3:24])[CH3:1])=[CH:14][C:13]([CH2:16][N:17]1[CH:21]=[N:20][CH:19]=[N:18]1)=[C:12]([C:22]#[N:23])[CH:11]=3

Komponenten

5

Edukt 3

HCID 702EthanolHCID 4311764Sodium borohydrideHCID 54516723HCID 54516723, Verbindung

Produkt 1

HCID 19858041HCID 19858041, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A mixture of 1,2-dihydro-1,1-dimethyl-2-oxo-8-(1H-1,2,4-triazol-1-ylmethyl)naphtho[2,1-b]furan-7-carbonitrile (0.07 g), ethanol (2 ml) and sodium borohydride (0.05 g) was stirred at room temperature for 18 h. Water (10 ml) was added, and the mixture was extracted with chloroform, and the extract was dried and evaporated to dryness under reduced pressure. The residue was recrystallised from ethyl acetate to give 1,2-dihydro-2-hydroxy-1,1-dimethyl-8-(1H-1,2,4-triazol-1-ylmethyl)naphtho[2,1-b]furan-7-carbonitrile, m.p. 219°-222°.

Aufarbeitung

  1. extractionthe mixture was extracted with chloroform
  2. customthe extract was dried
  3. customevaporated to dryness under reduced pressure
  4. customThe residue was recrystallised from ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-a6e6917a777848b0ad0154da5d361eb1
Quelldatensatz
uspto-grants-1990_04
Patentnummer
US04916148

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