Water → 2-Amino-3-(2-methyl-6-methoxycarbonylaminobenzylamino)pyridine

HRID 2073803

Reaktionsgleichung

Reaktionsgleichung von HRID 2073803
[NH2:1][C:2]1[C:7]([N:8]=[CH:9][C:10]2[C:15]([NH:16][C:17]([O:19][CH3:20])=[O:18])=[CH:14][CH:13]=[CH:12][C:11]=2[CH3:21])=[CH:6][CH:5]=[CH:4][N:3]=1.[BH4-].[Na+].O>CO.C(Cl)(Cl)Cl>[NH2:1][C:2]1[C:7]([NH:8][CH2:9][C:10]2[C:15]([NH:16][C:17]([O:19][CH3:20])=[O:18])=[CH:14][CH:13]=[CH:12][C:11]=2[CH3:21])=[CH:6][CH:5]=[CH:4][N:3]=1

Komponenten

6

Edukt 3

HCID 962WaterHCID 4311764Sodium borohydrideHCID 144998242-Amino-3-(2-methyl-6-methoxycarbonylaminobenzylideneamino)pyridine

Produkt 1

HCID 144998172-Amino-3-(2-methyl-6-methoxycarbonylaminobenzylamino)pyridineAusbeute 94,1 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 6212ChloroformLösungsmittel

Versuchsvorschrift

To a solution of 2-amino-3-(2-methyl-6-methoxycarbonylaminobenzylideneamino)pyridine (229 mg) in methanol (4.6 ml) and chloroform (4.6 ml) was added sodium borohydride (200 mg) and the mixture was stirred for 3.5 hours at room temperature. After water was added, organic layer was separated and dried over magnesium chloride. The solvent was evaporated under reduced pressure. The residue was triturated with diethyl ether to give 2-amino-3-(2-methyl-6-methoxycarbonylaminobenzylamino)pyridine (217 mg).

Aufarbeitung

  1. customorganic layer was separated
  2. dry with materialdried over magnesium chloride
  3. customThe solvent was evaporated under reduced pressure
  4. customThe residue was triturated with diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-7b8224e273b24a24b6518a7792f389bf
Quelldatensatz
uspto-grants-1990_04
Patentnummer
US04920129

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